London, August 1 : A new study has shed light on the genetic factors contributing to asthma susceptibility, paving way for better treatments of millions of sufferers around the world.
Researchers at the RIKEN Center for Genomic Medicine (CGM), together with colleagues at Kyoto University, Tsukuba University, Harvard University, and other medical institutions have identified three new loci associated with susceptibility to adult asthma in the Japanese population.
To clarify the genetic origins of adult asthma, the research group conducted a genome-wide association study on 1532 adult patients and 3,304 controls.
Among a total of roughly 460,000 genetic variants (called Single Nucleotide Polymorphisms or SNPs), the group identified five genetic regions associated with susceptibility to adult asthma, three of which had not previously been connected to the disease.
The associations were confirmed in a separate replication study on a population of 5,639 patients and 24,608 controls.
The study has been published in Nature Genetics. (ANI)