Indian scientists propose ‘electronic nose’ to detect TB from urine

Indian scientists propose ‘electronic nose’ to detect TB from urineWashington, Aug 4 : Indian scientists have found a fast and inexpensive way to detect and monitor the effectiveness of treatment for tuberculosis (TB) from the patients' urine.

Lead researchers Virander Singh Chauhan and Ranjan Kumar Nanda note that TB strikes an estimated 10 million people and kills 3 million each year, mostly in developing countries.

Health care workers diagnose the disease by identifying the TB bacterium in sputum or blood samples.

But current tests tend to be time-consuming, sometimes taking days or weeks to give results.

The tests also require the use of specially trained personnel or expensive equipment that might not be available in some areas.

The scientists describe an advance toward a urine test that overcomes these drawbacks.

They analysed so-called volatile organic compounds (VOCs) - substances that evaporate easily in the air - present in the urine of TB patients and compared them with VOCs in the urine of healthy patients.

The scientists found that infection with TB produces a distinct pattern of certain VOCs in much the same way that distinct fingerprint patterns can identify individuals.

The scientists suggest identification of these patterns sets the stage for developing a portable "electronic nose" that can quickly sniff urine samples to detect TB.

Their study appeared in the ACS' journal Analytical Chemistry. (ANI)