Washington, May 11: The pain, bloating, discomfort, and straining associated with constipation could soon have relief – thanks to the efforts of some Mayo Clinic researchers.

They have successfully conducted the clinical trial of a new drug called A3309, which provides relief from constipation.

The drug targets bile acid recycling in the body to promote bowel movements by softening stool and speeding up stool movement through the colon.

"The new medication is a novel approach which allows the delivery to the colon of normal substances produced by the patient''s own liver to induce a laxative effect," says Michael Camilleri, a gastroenterologist and Atherton and Winifred W. Bean Professor at Mayo Clinic.

In a Phase II study, researchers tested the effectiveness of A3309 for two weeks on patients with constipation.

The results showed that patients who took A3309 reported significantly less straining and softer stool during bowel movements compared to those who received placebo.

Researchers citied the main side effect of A3309 was abdominal discomfort and pain. According to Banny Wong, this occurred mainly before a bowel movement after which the pain and discomfort usually went away. (ANI)