NSAID use cuts risk of colorectal cancer death in postmenopausal women
Submitted by Jamie Williamson on Mon, 10/24/2011 - 08:58
Washington, Oct 24 : A new study has found that postmenopausal women who used nonsteroidal anti-inflammatory drugs for at least 10 years had a lower risk for death from colorectal cancer compared with women who do not these drugs.
“Our results suggest that nonsteroidal anti-inflammatory drug (NSAID) use is associated with lower colorectal cancer mortality among postmenopausal women who use these medications more consistently and for longer periods of time,” said Anna E. Coghill, M. P. H., a doctoral student in Epidemiology at the University of Washington and Fred Hutchinson Cancer Research Centre.
Coghill and her colleagues evaluated the association between aspirin and nonaspirin NSAID use and colorectal cancer mortality in 160,143 postmenopausal women enrolled in the Women’s Health Initiative (WHI), who did not report a history of colorectal cancer at baseline.
Researchers confirmed 2,119 cases of colorectal cancer through medical reports and verified 492 deaths due to colorectal cancer through a centralized medical record and death certificate review.
Coghill and colleagues found that reported use of NSAIDs such as aspirin, ibuprofen and prescription NSAIDs at baseline, by itself, was not associated with colorectal cancer mortality.
However, women in the study who reported using NSAIDs at both study enrolment and three years after study enrolment had an approximately 30 percent lower rate of death due to colorectal cancer compared with women who reported no NASID use or use at only one of these two time points.
Researchers also observed significant reductions in colorectal cancer mortality among women who reported at least 10 years of NSAID use at study enrolment compared with those who reported no use.
“The results of our study help to further clarify the importance of different durations of NSAID use over time for the risk for dying from colorectal cancer,” Coghill added.
The findings were presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011. (ANI)
