Anti-Depressants Are Not Of Much Use – A Study Report

Antidepressant-ProzacA new study says that new generation anti-depressant drugs including Seroxat and Prozac have small medicinal effect on the majority of patients.

The world’s well-known anti-depressant ‘Prozac’, which is taken by over 40 million people throughout the world, does not actually help improve the patient’s mental condition.

Found in India under the brands such as Prodac, Prodep and Fludac, the drug class known as ‘Fluoxetines’ has shown no clear medical advantage for both mildly depressed patients and those having harsh depression.

Research groups from the universities of Hull, Connecticut, Windsor and Institute for Safe Medication Practices, Pennsylvania examined data of 47 clinical tests of four common antidepressants such as fluoxetine (Prozac), venlafaxine (Effexor), nefazodone (Serzone) and paroxetine (Seroxat/Paxil), and found them less effectual than dummy tablets given to patients suffering from the disease (mild and moderate depression).

According to the study, published in the journal Plos Medicine, scientists said that the outcomes of clinical examinations showed that the majority of people with depression get well without taking any medicine.

Study lead author Prof. Irving Kirsch from the University of Hull UK told, “The difference in improvement between patients taking placebos and patients taking anti-depressants is not very great. And the effect for patients seems to be due to decreased responsiveness to placebo, rather than increased responsiveness to medication. Given these results, there seems little reason to prescribe anti-depressant medication to any but the most severely depressed patients, unless alternative treatments have failed to provide a benefit.”

“Meta-analyses of these medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance,” the researchers added up.