Parkinson's Disease

New gene involved in Parkinson's disease identified

New gene involved in Parkinson's disease identifiedWashington, June 5 - Researchers have identified a new gene involved in Parkinson's disease, a finding that may one day provide a target for a new drug to prevent and potentially even cure the debilitating neurological disorder.


Parkinson's disease could soon be history post groundbreaking discovery

Parkinson's DiseaseWashington, April 11 - Working with human neurons and fruit flies, researchers were able to identify and then shut down a biological process that seemed to trigger a particular form of Parkinson's disease present in a large number of patients.


Pesticide exposure linked to Parkinson's disease

Pesticide exposure linked to Parkinson's diseaseRome, May 28 : Researchers have analysed more than 100 global studies to show that exposure to pesticides, weed killers and solvents is likely to be associated with a higher risk for developing Parkinson's disease.

The research appears in the May 28 print issue of Neurology, the medical journal of the American Academy of Neurology.


Peppers, tomatoes lower risk of Parkinson's

Peppers, tomatoes lower risk of Parkinson'sWashington, May 10 : Scientists have linked foods like peppers and tomatoes containing small amount of nicotine to lowered risk of Parkinson's disease, says a study.

New research reveals that Solanaceae -- a flowering plant family with some species producing foods that are edible sources of nicotine -- may provide a protective effect against Parkinson's disease.


Voice recording could help detect early signs of Parkinson’s

Voice recording could help detect early signs of Parkinson’sLondon, September 27 : Parkinson's disease could be spotted years before serious symptoms develop by studying a simple voice recording.

Scientists at Massachusetts Institute of Technology have developed a computer programme that is able to recognise the tremors, breathiness and weakness in the voice, which are thought to be early indicators of the condition, the Daily Mail reported.


New genetic mutation linked to Parkinson''s disease identified

New genetic mutation linked to Parkinson''s disease identifiedWashington, July 16 : Researchers have identified the sixth known inherited gene defect causing Parkinson's disease (PD), paving the way for new target therapies that may halt or cure the debilitating neurodegenerative disease.

The mutation was identified in a large Swiss family with Parkinson''s disease, using advanced DNA sequencing technology.


Mutation in protein-sorting gene linked with Parkinson’s disease

 Mutation in protein-sorting gene linked with Parkinson’s diseaseWashington, July 15 : Two new studies have identified a mutation associated with an inherited form of Parkinson’s disease (PD), which is a devastating incurable disease that leads to tremors and problems with movement and coordination.

The studies provide new insight into the pathogenesis of late-onset PD and present compelling evidence that implicates a novel protein-recycling pathway in neurodegeneration.

“Previous studies of familial parkinsonism have identified pathogenic mutations in several genes, providing mechanistic insight and novel targets for therapeutic intervention,” the lead authors of one of the studies, Dr. Carles Vilarino-Guell and Dr. Matthew J. Farrer from the University of British Columbia, said.

“In our study, we identified a pathogenic mutation associated with PD in a Swiss family where multiple individuals presented with disease.

“Confirmation of the discovery was an international effort embraced by neurologists in Canada, Israel, Norway, Switzerland, Taiwan, Tunisia, and the United States,” they stated.

A second independent study, led by Dr. Tim M. Strom from the Institute of Human Genetics in Neuherberg, Germany and Dr. Alexander Zimprich from the Medical University of Vienna, used the same sophisticated sequencing techniques to look for causal mutations in a family from Austria with multiple incidences of late-onset PD.

Both groups discovered the same mutation in the vacuolar protein-sorting-associated protein 35 (VPS35) gene in affected family members.

The VPS35 protein is part of a complex called the “retromer” that mediates the intracellular transport and sorting of membrane-associated cell-surface proteins that are going to be recycled or destroyed.

“A single variant in the VPS35 gene was found in all affected family members investigated, was absent in general population samples, and was detected in two additional PD families,” Dr. Strom and Dr. Zimprich said.

Taken together, the findings suggest that the VPS35 mutation is the genetic determinant of the late-onset PD examined in the studies and that perturbation of retromer-mediated protein sorting is linked with neurodegeneration.

Cell Press has published the study in the July 9 issue of The American Journal of Human Genetics. (ANI)


Soon, brain cells made from patients’ skin could treat Parkinson''s

Soon, brain cells made from patients’ skin could treat Parkinson''sLondon, July 07 : Researchers have found a novel way to treat people with Parkinson''s disease - brain cells made from patients’ own skin.

Two teams of researchers have independently worked out how to turn skin cells into specialised neurons that make dopamine. This neurotransmitter, which is vital for mobility, is depleted in the brains of people with Parkinson''s, reports New Scientist.


Why debilitating Parkinson''s disease affects your movements

 Why debilitating Parkinson''s disease affects your movementsWashington, July 2: For three out of every four people who develop Parkinson's disease (PD), the disease begins with a trembling or shaking in one of the hands, arms, legs, jaw, and face.

Others with PD may experience stiffness of the limbs and trunk; slowness of movement; and impaired balance and coordination as symptoms.

All this results from loss or loss of function of nerve cells in the brain that coordinate movement.


Lithium greatly prevents brain damage linked with Parkinson’s disease

Lithium greatly prevents brain damage linked with Parkinson’s diseaseWashington, June 25: A study has found that lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson's disease (PD).

The Buck Institute for Research, which carried out the study on a mouse model of the condition, is currently working toward initiating a Phase IIa clinical study of lithium in humans in conjunction with standard PD drug therapy.


New clues about protein linked to Parkinson’s disease found

 New clues about protein linked to Parkinson’s disease found Washington, June 18: A team of researchers has found structural clues about the protein linked to Parkinson’s disease (PD), which ultimately could lead to finding a cure for the degenerative neurological disorder. The study is by researchers at the Keck School of Medicine of the University of Southern California (USC).


Cause of severe sleep disorder closely linked to Parkinson''s discovered

 Cause of severe sleep disorder closely linked to Parkinson''s discovered Washington, June 16: Researchers at the University of Toronto have identified a potential cause for a severe sleep disorder that could also have implications for Parkinson’s disease and other neurodegenerative diseases.


Music and drama offer physical and emotional benefits to Parkinson’s patients

 Music and drama offer physical and emotional benefits to Parkinson’s patients Washington, June 15 : A Northwestern hospital is offering a music and drama therapy program for patients with Parkinson’s disease to address many of the physical and emotional symptoms of the disease.

Creative Arts for Parkinson’s offered through Parkinson’s Disease and Movement Disorders Center is lead by specially trained music and drama therapists from the Institute for Therapy through the Arts (ITA).


Pesticide exposure near workplace puts people at Parkinson''s disease risk

Pesticide exposure near workplace puts people at Parkinson''s disease riskWashington, May 27 : A study has found that people who are exposed to pesticides near workplace are at a high risk of developing Parkinson''s disease.

In a follow up study, the researchers at the UCLA School of Public Health found that the combined exposure to pesticides ziram, maneb and paraquat near any workplace increased the risk of Parkinson''s disease


Parkinson''s disease linked to increased risk of prostate cancer, melanoma

 Parkinson''s disease linked to increased risk of prostate cancer, melanoma Washington, April 7 : University of Utah School of Medicine researchers have found strong evidence that Parkinson''s disease is associated with an increased risk of prostate cancer and melanoma.

They also discovered that this increased cancer risk also extends to close and distant relatives of individuals with Parkinson''s disease.


Study provides new insight into Parkinson''s disease

Study provides new insight into Parkinson''s diseaseWashington, Apr 5: A new study has provided the first link between the most common genetic risk factor for Parkinson''s and the hallmark accumulation of a protein called alpha-synuclein within the brains of people with Parkinson''s.

"This study addresses a major riddle in Parkinson''s disease," explains Michael Schlossmacher, who holds the Canada Research Chair in Parkinson''s disease at the Ottawa Hospital Research Institute.


Early symptoms of Parkinson''s disease revealed in dream sleep

 Early symptoms of Parkinson''s disease revealed in dream sleepWashington, March 29: Danish researchers have discovered that very early symptoms of Parkinson's disease may be revealed in dream or REM sleep.

Parkinson's disease is a brain disease best known for the trembling it causes. It is an incurable, chronic disease and gradually affects the muscles and mental capacity, seriously afflicting the lives if the patient and his or her immediate relatives.


New study could lead to potential drug targets for schizophrenia, Parkinson''s

New study could lead to potential drug targets for schizophrenia, Parkinson''s Washington, Mar 12: A new study from the Scripps Research Institute and University of Pennsylvania could pave the way for potential drug targets for diseases ranging from schizophrenia to Parkinson''s disease.


Potential therapeutic target for Parkinson''s, Alzheimer''s identified

Potential therapeutic target for Parkinson''s, Alzheimer''s identifiedWashington, Mar 12: Scientists have identified a potential therapeutic target to slow changes that lead to neurodegenerative disorders such as Parkinson''s and Alzheimer''s diseases.

Cell biologists pondering the death of neurons - brain cells - said that by eliminating one ingredient from the cellular machinery, they prolonged the life of neurons stressed by a pesticide chemical.


‘Key player’ that facilitates Parkinson''s disease found

‘Key player’ that facilitates Parkinson''s disease foundWashington, March 04: Johns Hopkins scientists have discovered that PARIS - the protein - facilitates the most common form of Parkinson''s disease (PD).

The findings could lead to important new targets for treatment.


Ibuprofen may reduce risk of Parkinson''s disease

 Ibuprofen may reduce risk of Parkinson''s disease Washington, March 03 ): Adults who regularly take ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), have about one-third less risk of developing Parkinson''s disease than non-users, shows a new study by Harvard School of Public Health (HSPH) researchers.


Naturally occurring brain mechanism ups Parkinson''s understanding

Naturally occurring brain mechanism ups Parkinson''s understandingWashington, Feb 12: A University of South Florida study has suggested that targeting the neuroinflammatory causes Parkinson''s disease with a brain chemical signal may lead to better understanding of the disease and pave way for better therapies.


New research offers hope to Parkinson’s disease patients

stem-cellsWashington, Feb 9 : A new research on rats with Parkinson’s disease has shown that intranasal delivery of stem cells to the brain could significantly contribute to the improvement of motor function.

The findings highlight the potential for a non-invasive approach to cell therapy delivery in Parkinson disease – a safer and effective alternative to surgical transplantation of stem cells.


New model paves way for drugs to fight Parkinson''s disease

New model paves way for drugs to fight Parkinson''s diseaseWashington, Feb 2: New drugs to combat Parkinson''s disease (PD) may soon be available, for researchers have developed a new mammalian model for studying a specific gene mutation commonly found in PD sufferers.


New tests to detect Parkinson's disease early on

New tests to detect Parkinson's disease early onLondon, Sep 27 - Parkinson's disease could be identified years before it begins to show symptoms.

Researchers have identified key markers that may indicate whether a patient is at risk of developing the neurodegenerative disease.

Currently its patients are diagnosed through an evaluation of symptoms, by which time the disease is already well advanced.


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