Sweet nanoparticles to target stroke
Berlin: Materials resulting from chemical bonding of a sugar with a kind of nanoparticle may help reduce cell damage and inflammation occurring after stroke, scientists say.
A research team from the Max Planck Institute in Germany has tested these materials on mice, opening the door to potential new drugs for the cerebrovascular accident.
The majority of stroke occurs when the blood vessels that reach the brain are blocked by clots or fatty deposits which decrease the flow of blood towards its cells.
It is then that an ischemic attack occurs, a pathology that leads to the degeneration of neurons, which can be fatal and not many drugs can treat.
Now, German and Swiss scientists have discovered that the combination of two substances help to reduce inflammation and the brain volume affected after a cerebrovascular accident.
This is glucosamine, an amino sugar commonly used to treat arthritis and arthrosis; and certain derivatives of fullerenes, hollow and spherical structures formed by many carbon atoms, researchers said.
Before now it was known that the fullerenes capture chemical radicals well which makes them act as neuroprotective agents, while the glucosamine brings down the inflammation.
What the researchers have done is chemically bond the two compounds to produce what is known as 'glyconanoparticles'. These have subsequently been administered to laboratory rats which then had a cerebrovascular accident induced.
The results, published in the journal Experimental Neurology, conclude that this combination of fullerene derivatives and glucosamine reduces cell damage and inflammation after a stroke, according to the MRI scans of animal brains and the improvement of their neurological symptoms.
"Our study confirms that it is possible to couple fullerenes with sugars in order to combine their protective effects and in this way, to obtain new materials which may help to prevent and to treat stroke," said Guillermo Orts-Gil, from the Max-Planck Institute of Colloids and Interfaces (Germany) and co-author of the research.
"Although the present study was carried out on mice, the results indicate that these sweet buckyballs are potential new drugs for treating stroke also in humans. However, this must be taken with caution, since what works in mice does not necessarily will work in the same way in humans," said Orts-Gil.--PTI