Retina cells may help in treating jet lag
Washington D.C. [USA], April 18 : Briton researchers have found a new group of cells in retina of eyes that can directly affect the biological clock of the people who experience jet lag.
According to researchers, a new group of cells in the retina that directly affect the biological clock by sending signals to a region of the brain which regulates our daily (circadian) rhythms, thereby opening a new therapeutic possibilities to manipulate the retina's signals and alter the body's responses to light changes.
The suprachiasmatic nucleus (SCN) is a region of the brain, which co-ordinates the circadian rhythm using many different signalling molecules, including the neurohormone vasopressin.
This research shows that the retina has its own population of vasopressin-expressing cells which communicate directly to the SCN and are involved with regulating the circadian rhythm.
This gives an insight into how the biological clock is regulated by light and could open up new therapeutic opportunities to help restore altered circadian rhythms through the eye.
"Our exciting results show a potentially new pharmacological route to manipulate our internal biological clocks," said study's lead investigator Mike Ludwig from the University of Edinburgh in England.
"Studies in the future which alter vasopressin signalling through the eye could lead to developing eye drops to get rid of jet lag, but we are still a long way off from this," Ludwig added.
Biological clocks are synchronised to light-dark changes and are important to regulate patterns of body temperature, brain activity, hormone production and other physiological processes.
Disruption of this can lead to health problems such as gastrointestinal and cardiovascular disorders, depression and an increased risk of cancer.
The researchers interfered with the signalling of light information sent to the SCN in rats.
Using a series of physiological tests, they showed that vasopressin-expressing cells in the retina are directly involved in regulating circadian rhythms.
The study appeared in the Journal of Physiology. (ANI)
- Massachusetts casinos all set to reopen this Monday, albeit under operating restrictions
- New Jersey has been too slow to allow its economic engine to restart: Senate President Sweeney
- Philippines Offshore Gaming Operators leading to kidnappings and chaos in Manila
- Two more Churchill Downs Incorporated casinos to reopen this week
- Nolimit City reveals latest online slot release Bonus Bunnies
- HG Vora acquires 5.1% stake in William Hill for $149 million, fueling sale speculations
- British bookmaker William Hill’s American subsidiary completes acquisition of CG Technology
- Atlantic City casinos allowed to resume smoking, drinking on gaming floors
- Casino sector isn’t yet out of the woods and faces difficult days ahead: BGC
- French casino operator Partouche join forces with Pixel Companyz to create first Japan-led IR consortium