Men and Women have different Activated Immune Cells during Pain Response

A research published in the journal Nature Neuroscience has tested the levels of pain sensitivity among male and female. To know the same, study researchers used male and female mice and came to know both genders experience the same levels of pain sensitivity. But they were activated through different immune cells during response.

The researchers wanted to know the gender differences in pain response, so that new therapies could be more successful when they enter the market. In the experiment, the male and female mice were injured on foot and were then given medicine.

It was noticed that after receiving the medicine, male mice felt better, but female mice showed 'as much touch sensitivity as before (the medicine)'. In earlier studies it has been shown that immune cells called microglia transmit signals from an injury site signaling how much an injured part should pain.

But now a new research from McGill University, Duke University and Canada's Hospital for Sick Children has stated that this immune cell is only responsible for pain signaling in men. In the case of women, T-cells are responsible for pain sensation in women.

In the experiment, the study researchers interfered with microglia functioning in male and female mice. It was found that it could only stop pain in male mice. "We believe that mice have very similar nervous systems to humans. especially for a basic evolutionary function like pain, so these findings tell us there are important questions raised for human pain drug development", said study researchers.