RNA-based medications may prevent premature labour

RNA-based medications may prevent premature labourA new research has found that microRNA's interact with hormones to prevent the risk of premature labor.

Researchers looked at pregnant mice, and found that the hormone progesterone and the proteins called ZEB1 and ZEB2 play role in controlling onset of labor.

The study findings indicate that progesterone keeps the levels of microRNA down and that of proteins up during pregnancy.

The senior author, Carole Mendelson explained that the levels of progesterone increases and that of ZEB proteins decrease with RNA-based drugs, which controls the contraction of uterus.

The suppression of ZEB1 proteins leads to production of miR-200 molecules, which further increases the miRNA's.

Researchers said that bacterial infection, which leads to inflammation is the main cause of early labor in some women.

Finally, scientists looked at the gene activity in cultured human cells from uterus walls to confirm that whether same phenomenon occurs in humans.

Currently, there are few treatment s available for controlling preterm labor.

The new findings are very important as these will help in reducing infant mortality rate and disability in developed countries.

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