United States

Imbalance of iron linked to prion disease-related neuronal demise

Washington, March 15 : An Indian-origin researcher at Case Western Reserve University School of Medicine has found that imbalance of iron homeostasis is a common feature of prion disease-affected human, mouse, and hamster brains.

Dr. Neena Singh, who worked in collaboration with researchers from Creighton University, says that her team's findings provide new insight into the mechanism of neurotoxicity in prion disorders, and novel avenues for the development of therapeutic strategies.

Unlike other neurodegenerative conditions, prion disorders are sporadic, inherited, and infectious, and affect both humans and animals.

Mad cow disease in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease in humans are some of its examples.

Federer says fatherhood won't derail his tennis

Federer says fatherhood won't derail his tennis Indian Wells, California  - Roger Federer insisted on Saturday that his impending summer fatherhood won't impact his tennis as he strives for more history in the sport.

"I've always had the dream that once I became number 1, that if I have a child I hope I have it early enough so he can see me playing," he said after reaching the third round of the Indian Wells Masters 7-6 (7-4), 6-4 over Marc Gicquel.

"This is very exciting, you know.

Computer and internet briefs

Computer and internet briefsWashington  - Zip files are a way of life. The compression method known as Zip can reduce files to a fraction of their original size, and it's used by people the world over. The trouble is, the major programs used to decompress Zip files - WinZip and WinRAR - are both commercial. Luckily, there's a free tool called 7-Zip that does just about everything the fee-based utilities do. Get 7-Zip at http://www.7zip.com.

Depleted Dementieva loses battle against fatigue

Depleted Dementieva loses battle against fatigueIndian Wells, California  - Exhausted Elena Dementieva, winner of her first 15 matches this season, hit the wall as she crashed out to Czech Petra Cetkovska 6-7 (2-7), 6-2, 6-1 Saturday at the Indian Wells Masters.

"I shouldn't have come here because I didn't have enough time to recover after playing so many matches in the beginning of the year," said the Russian Olympic gold medallist. "I just needed a much longer break to get ready to play at my best."

ROUNDUP: Obama: "There are no sides" over stimulus at G20

US President Barack ObamaWashington  - US President Barack Obama insisted Saturday

Below-par Murray works his way to victory

Andy MurrayIndian Wells, California  - Andy Murray began a slow return to form after overcoming a virus that had laid him low for more than a week, advancing to victory in his opening match Saturday at the Indian Wells Masters 7-5, 6-3 over Albert Montanes.

The Scot fourth seed admitted that while he was not in top form, he did turn in a respectable showing against an opponent who has won a mere two matches this season.

"I thought I did well. I wanted to just give it 110 per cent," said the winner of two ATP titles so far in 2009.

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