According to the U.S. researchers, combination hormone therapy increases heart disease risk in women as analyzed from the Women's Health Initiative.

Researchers from the Harvard School of Public Health and the National Heart, Lung and Blood Institute re-analyzed data from the landmark Women's Health Initiative clinical trial of the

effects of combination hormone therapy -- progestin in combination with estrogen -- in 16,608 post-menopausal women with an intact uterus, ages 50-79 years at enrollment.

Annals of Internal Medicine published the study which found a trend toward an increased risk of heart disease during the first two years of hormone therapy among women who began therapy

within 10 years of menopause, and a more marked elevation of risk among women who began hormone therapy more than 10 years after menopause.

Acting director of the National Heart, Lung, and Blood Institute, Dr. Susan B. Shurin, said in a statement "Today, most women who take hormone therapy for menopausal symptoms begin

therapy shortly after menopause. Based on today's report, even these women appear to be at increased risk of heart disease for several years after starting combination hormone therapy. It is

clearer than ever that women who are considering post-menopausal hormone therapy for menopausal symptoms should discuss their risk of heart disease and other risks -- such as breast cancer,

stroke, and dangerous blood clots -- with their doctors before starting therapy." (With Input from Agencies)